RESEARCHES ON PYRIMIDINES: PYRIMIDINE-NUCLEOSIDES

Metabolism of pyrimidines and pyrimidine nucleosides by Salmonella typhimurium.

The pathways by which uracil, cytosine, uridine, cytidine, deoxyuridine, and deoxycytidine are metabolized by Salmonella typhimurium are established. The various 5-fluoropyrimidine analogues are shown to exert their toxic effects only after having been converted to the nucleotide level, and these conversions are shown to be catalyzed by the same enzymes which similarly convert the natural subst...

Prebiotic Synthesis of Pyrimidine Nucleosides

Pyrimidine studies. II. Effect of 5-bromodeoxyuridine and related nucleosides on incorporation of precursors into nucleic acid pyrimidines.

As p a r t of a s tudy related to the effect of selected compounds on the incorporat ion of precursors into nucleic acid pyr imidines (8, 10), 5bromodeoxyur id ine ( B r U D R ) and a number of re lated nucleosides have been tested. I t was noted in a pre l iminary repor t t h a t the specific ac t iv i ty of D N A thymine was appreciably depressed when slices of h u m a n tumor t r ansp lan t ...

Metabolism of pyrimidine L-nucleosides.

The intraperitoneal application of L-nucleosides (L-Cyd, L-Urd, L-dThd) to mice results in distribution of these compounds into tissues of the organism and their gradual excretion in the unchanged form. The residual level has been observed with L-ribonucleosides only and contains in addition to the L-nucleoside its 5'-phosphate. The phosphorylation in vivo is catalyzed by nucleoside-kinase and ...

In Plane Vibration of Pyrimidine and some Deuterated Pyrimidines

On the basis of 102 assigned frequencies to in plane vibrations of pyrimidine, pyrimidine-2-d2, pyrimidine-2, 5-d2, pyrimidine-4,6-d2, pyrimidine-2,4,6-d3 and pyrimidine-d4, 35 valance force field constants including 14 principals and 21 interaction force constants are calculated. New assignments are suggested for n<su...